Which champion is in the most jeopardy of losing their title at WWE Fastlane?

WWE Champion AJ Styles in the Six-Pack Challenge where he does not have to be pinned to lose the title.

SmackDown Tag Team Champions The Usos against their greatest rivals, The New Day.

SmackDown Women’s Champion Charlotte Flair as she takes on the determined Ruby Riott.

United States Champion Bobby Roode against the grizzled veteran, Randy Orton.